CCMA Anatomy and Physiology Practice Questions
24 free questions covering all eight current NHA CCMA Anatomy and Physiology knowledge statements, with instant rationales and no sign-up.
24 free CCMA anatomy and physiology practice questions — three for every statement in the current NHA test plan. Instant rationales. No sign-up.
By Castleport Test Prep Editorial Team · Last verified: August 11, 2026
Official exam facts on this page were checked against the current NHA CCMA Detailed Test Plan and the current NHA Candidate Handbook on the date above.
Start the CCMA Anatomy and Physiology coverage drill
Choose one question from each current NHA knowledge statement for a fast check, or answer all three questions per statement for a more granular gap map. Your result is study guidance, not an NHA score prediction.
Anatomy and Physiology is 8 of the 150 scored questions on the NHA CCMA exam — 5.3% of the scored-item blueprint. These 24 free CCMA anatomy and physiology practice questions cover all eight knowledge statements NHA publishes for that domain, with a rationale and a source on every item. You'll get a gap map by statement, not a pass prediction.
Eight. That's it.
If you were expecting a bigger number, you're not wrong to be confused — a lot of study material still says twelve. That number was real once. And here's the part almost nobody tells you: the current plan explicitly threads anatomy and body-site knowledge through 25 task or knowledge statements outside this domain. We counted them.
Both of those things are below, with the source documents.
Best for you if:
- You're sitting the current NHA CCMA exam and want A&P questions right now
- You need to tell a body-systems gap apart from a disease-process gap
- You saw "8 questions" one place and "12 questions" another
- Your score report flagged Anatomy and Physiology
This is the wrong page if:
- You're taking the CMA (AAMA), RMA (AMT), or NCMA (NCCT) — different organizations, different blueprints. Start at CMA vs CCMA vs RMA instead.
- You need registration, eligibility, fees, accommodations, or retake rules → the CCMA exam hub
- You want a mixed-domain baseline across all seven domains → the free CCMA diagnostic
- You're looking for recalled or "actual" exam questions. We don't have those and won't publish them. More on that below.
Castleport Test Prep is an independent exam-prep publisher. This drill is ours, built from the public NHA test plan. It is not an official NHA practice test and does not contain live or recalled exam items.
What do these CCMA anatomy and physiology practice questions cover?
They cover all eight knowledge statements in the current NHA CCMA Anatomy and Physiology domain: cell structure; anatomical structures, locations and positions; major body systems and organs; organ-system interactions and homeostasis; signs, symptoms and causes of common diseases and injuries; diagnostic measures and treatment modalities; incidence, prevalence, risk factors and comorbidities; and epidemics and pandemics. Each statement gets three original questions.
A quick definition, because the whole page depends on it. NHA publishes a test plan — the free public document that lists what the exam can ask. Inside it, each domain breaks into numbered knowledge statements (things you need to know) and task statements (things you need to be able to do). Anatomy and Physiology, which NHA calls Domain 2, has eight knowledge statements numbered k35 through k42 and zero task statements. It's a pure knowledge domain.
That's convenient for us. Eight statements, three questions each, 24 questions, complete coverage. Here's the map:
| Statement | Subdomain | What it covers | Questions here |
|---|---|---|---|
| k35 | 2A Body Structures and Organ Systems | Cell structure | 3 |
| k36 | 2A | Anatomical structures, locations and positions | 3 |
| k37 | 2A | Major body systems, organs, structure and function | 3 |
| k38 | 2A | Organ-system interactions and homeostasis | 3 |
| k39 | 2B Pathophysiology and Disease Processes | Signs, symptoms and causes of common diseases and injuries | 3 |
| k40 | 2B | Diagnostic measures and treatment modalities | 3 |
| k41 | 2B | Incidence, prevalence, risk factors and comorbidities | 3 |
| k42 | 2B | Epidemics and pandemics | 3 |
Source: NHA CCMA Detailed Test Plan, read in full August 11, 2026.
One honest limit, stated up front. Three per statement is our coverage design. NHA publishes eight scored items for the domain but never says how those eight get split across k35–k42. So don't read our even 12/12 balance between 2A and 2B as a prediction that the real exam splits 4-and-4. We balanced it that way to test every statement, not to forecast the form.
→ Start Quick 8 — one question from every statement, about four minutes. Or take the Full 24 if you want the statement-level map.
How many anatomy and physiology questions are on the CCMA exam?
Eight of the 150 scored items — 5.3% of the scored-item blueprint by our calculation. The exam presents 180 questions in three hours: 150 that count toward your score and 30 unscored pretest items. NHA says candidates are not told which questions are scored and which are pretest. Anatomy and Physiology is the second-smallest domain; only Medical Law and Ethics is smaller, at 7 scored items.
| Fact | Current NHA CCMA plan |
|---|---|
| Anatomy and Physiology scored items | 8 |
| Total scored items | 150 |
| Unscored pretest items | 30 |
| Total questions presented | 180 |
| Exam time | 3 hours |
| A&P share of scored items | 5.3%* |
| Smaller domain | Medical Law and Ethics, at 7 items |
\* Item counts are NHA's. The percentage is a Castleport calculation: 8 ÷ 150.
The test plan — not the score report — is the official source for the 8. NHA says its detailed score report provides diagnostic performance across major content areas. The public handbook does not say that the report prints each area's official item count next to the row, so this page does not use a candidate report as the source of that number.
Eight items is above NHA's reporting cutoff. The handbook says a content area with five or fewer questions receives N/A instead of a performance category because limited item counts create statistical-reliability concerns. Under the current plan, A&P clears that threshold by three and is eligible for an Above, Near, or Below diagnostic category rather than N/A. Hold that thought; it matters for retakers, and we come back to it.
Is CCMA anatomy and physiology 8 questions or 12?
Eight, under the current plan. Twelve was correct under the older plan based on NHA's 2016 job analysis, which listed Microbiology as a third A&P subdomain. Both documents remain downloadable from NHA, which is exactly why the wrong number keeps circulating.
This is the most useful thing on this page, so let's do it properly. Here are the two NHA summaries side by side, both read on August 11, 2026:
| Fact | Older plan based on 2016 job analysis | Current plan based on 2022 job analysis |
|---|---|---|
| A&P scored items | 12 (8%) | 8 (5.3%*) |
| A&P subdomains | Body structures and organ systems; Pathophysiology and disease processes; Microbiology | Body structures and organ systems; Pathophysiology and disease processes |
| Clinical Patient Care | 81 (54%) | 84 (56%*) |
| Infection control | 12 (8%) | 15, now called Infection Control and Safety |
| Administrative Assisting | 19 or 20 (13%) | 12 |
| Total scored | 150 | 150 |
\* Percentages for the current plan are Castleport calculations from NHA's official item counts. The 2016 percentages are printed in NHA's own summary. Sources: 2016 summary test plan · current Detailed Test Plan. NHA made the current CCMA 3.0 exam available on January 10, 2024.
Read that table twice, because it explains almost every disagreement you'll find online.
Microbiology was split, not simply deleted or moved as one block. NHA's official 2016-to-2022 crosswalk maps the old 2C1 cell-structure statement to current k35 inside A&P. It maps old 2C2–2C4 — common pathogens, organisms and micro-organisms, infectious agents, the chain of infection, transmission and growth conditions — to current k92–k94 inside Infection Control and Safety, which sits under Clinical Patient Care.
So if you've been grinding pathogens as "A&P," you're studying real testable content. You're just studying it for the wrong current domain, and it'll be scored as Clinical Patient Care.
Here's your 30-second staleness test. If a study page tells you A&P is 8%, check what it says for Clinical Patient Care. If that says 54%, you're reading the retired plan.
We ran that test on prominent pages candidates still find:
- Study.com's published domain weights are 10% / 8% / 54% / 5% / 13% / 5% / 5%. That is the retired plan's percentage pattern across all seven domains, not the current one.
- The Quizlet set titled "NHA CCMA: Anatomy & Physiology" still describes itself as covering Body Structure & Organ Systems, Pathology & Disease, Microbiology — 12 questions. That's the old structure.
Both were read directly on August 11, 2026. We're not calling anyone dishonest — the old PDF is still live on NHA's own site, and that's a genuinely easy trap. But you're the one who pays for it on test day.
→ Don't take our word for it. NHA gives the current test plan away free — download it here and look at page one. Domain 2, eight items, two subdomains. Thirty seconds, and you never have to wonder again.
Should I take this A&P drill or the full CCMA diagnostic first?
Take this drill first when Anatomy and Physiology is the named problem — your score report flagged it, your old material says 12, or you need to separate 2A body systems from 2B disease processes. Take the free Castleport CCMA diagnostic first when you do not know which of the seven domains deserves your next study block.
The diagnostic is live: 25 original questions, instant results by top-level domain, rationales on every item, no sign-up. The 50 free CCMA flashcards are the better first move when your problem is basic recall rather than applying the concepts in questions.
Need registration, fees, eligibility, accommodations, or retake rules? Use the CCMA exam hub. Need to know what a medical assistant may legally do at work? That is a different question, and the answer varies by state; use medical assistant scope of practice by state.
→ Take the free Castleport CCMA diagnostic — 25 questions, instant results by domain, no email.
We'll go first: a 25-question diagnostic gives A&P only 1.3 expected items
Our free CCMA diagnostic is 25 questions. It does not publish a fixed promise that exactly one or two of those questions will be A&P. Under a blueprint-proportional model, however, Anatomy and Physiology gets 1.33 expected items: 25 × 8 ÷ 150. One or two sampled questions cannot support a stand-alone readiness verdict — and that is the honest reason this page exists.
We're saying it out loud because the math is the same on every short proportional practice test, ours included, and the proportional limit is easy to miss:
| Current domain weight | Expected items in a 25-question proportional test |
|---|---|
| Clinical Patient Care — 84 of 150 | 14.0 |
| Foundational Knowledge — 15 of 150 | 2.5 |
| Each 12-item domain | 2.0 |
| Anatomy and Physiology — 8 of 150 | 1.3 |
| Medical Law and Ethics — 7 of 150 | 1.2 |
Only A&P and Medical Law and Ethics fall below two expected questions; the three 12-item domains land exactly at two. A 0-for-1 result is one miss, not a domain diagnosis.
That's not a reason to skip the diagnostic. Use it for what it's actually good at: telling you which of the seven top-level domains deserves your next study block. Under proportional weighting, Clinical is the only domain that reaches six expected items at this length. Then use this page for the A&P detail the diagnostic can't reach.
And a second admission, since we're here. Larger courses and flashcard sets exist. If sheer repetition volume is what you want, go use one — genuinely.
Just know what volume buys you here. There are eight scored A&P items on the current exam. Answering your 400th cell-structure question cannot earn you a ninth. That's the whole argument for what comes next.
We don't offer a pass guarantee, and this drill doesn't predict a score. There's no published way to convert a third-party practice percentage into an NHA scaled score, so anyone who offers you a readiness number is estimating.
Why do CCMA anatomy and physiology questions include disease and pandemics?
Because half the domain isn't anatomy. NHA splits Domain 2 into two subdomains: 2A Body Structures and Organ Systems, and 2B Pathophysiology and Disease Processes. Four of the eight statements sit in 2B, covering disease signs and causes, diagnostics and treatments, incidence and risk factors, and epidemics and pandemics. A body-systems-only review leaves half the published statement set untouched.
Look at what 2B actually asks for:
- k39 — signs, symptoms and etiology of common diseases, conditions and injuries
- k40 — diagnostic measures (labs, imaging, biopsies) and treatment modalities (infusion, chemotherapy, medication, surgery)
- k41 — incidence, prevalence, risk factors and comorbidities
- k42 — epidemics and pandemics
Two quick definitions, since k41 turns on them. Incidence counts new cases in a period. Prevalence counts all cases that exist at a point or over a period, new and old together. Mixing those up is an easy way to miss a question, and a body-systems-only review may never teach you the difference.
Now check the prominent free A&P quiz we rechecked. It lists fifteen topics — body organization, anatomical position, body cavities, skeletal, muscular, cardiovascular, respiratory, digestive, nervous, endocrine, urinary, reproductive, integumentary, lymphatic and immune, and homeostasis. Every one maps to 2A. Not one of the four published 2B statements appears in that topic list.
That's the gap. A page can promise to cover your A&P domain and still leave half of its published statement set untouched.
Careful, though, because this is where it's easy to overshoot. Four of eight statements being in 2B does not mean four of eight items come from 2B. NHA doesn't publish the within-domain split, so nobody knows the real ratio — including us. What you can say for certain is that 2B is published, testable, and absent from that competitor's stated topic list. Study it accordingly.
Where your CCMA anatomy knowledge is tested outside the A&P domain
Anatomy and Physiology is 8 scored items, but the current test plan explicitly reuses anatomy, body-site, positioning, blood-component, sensory-testing, pulmonary-function and electrode-placement knowledge outside Domain 2. Using a strict rule, we found 25 task or knowledge statements outside A&P whose own wording directly names anatomy, an anatomical location, a body structure or site, or a body-system function.
This is the block we built this page for. It is Castleport's own map, built directly from the current plan.
Our counting rule, so you can check us: we counted a task or knowledge statement only when NHA's own wording directly names anatomy, positioning, a body structure or site, blood components, a sensory or pulmonary function, or electrode placement. We did not count every clinical statement that could indirectly benefit from anatomy. Every code below is in the free PDF. Go argue with us.
| Where the plan explicitly reuses A&P | Official scored items in that section | Explicit cross-domain statements | Codes counted |
|---|---|---|---|
| Foundational Knowledge and Basic Science | 15 | 1 | k13 |
| Patient Intake and Vitals | 14 | 5 | task 3A6; k49; k51; k52; k57 |
| General Patient Care | 28 | 5 | task 3B9; k61; k70; k72; k76 |
| Point of Care Testing and Laboratory Procedures | 9 | 5 | tasks 3D6 and 3D8; k118; k119; k120 |
| Phlebotomy | 12 | 5 | tasks 3E4 and 3E5; k122; k130; k131 |
| EKG and Cardiovascular Testing | 6 | 4 | task 3F2; k150; k151; k153 |
| Total outside A&P | 84 section items | 25 statements |
Castleport analysis of the NHA CCMA Detailed Test Plan, August 11, 2026. The section item counts are official; the counting rule, statement selection and total are ours. This does not mean there are 84 extra anatomy questions. NHA allocates items to sections, not one item to every statement.
A few rows are worth reading closely, because NHA's own wording gives the game away:
- k131, under Phlebotomy, literally begins with the word Anatomy — anatomy, skin integrity, venous sufficiency, contraindications. Vein anatomy is named in the plan.
- Task 3F2, under EKG, says identify types of leads and proper anatomical electrode placement. Knowing V1 through V6 by intercostal space is anatomy. It's scored as EKG.
- k72, under General Patient Care, covers needle angle, gauge, length and injection site. Deltoid, vastus lateralis, ventrogluteal — that's surface anatomy, scored inside a 28-item subdomain.
- k49 is pulse in various locations. Radial, brachial, carotid, femoral, popliteal, pedal. Surface anatomy, scored as Patient Intake and Vitals.
- k13, positional and directional terminology, sits in Foundational Knowledge, not A&P. To be precise, k36 inside A&P also covers anatomical structures, locations and positions, so directional language genuinely straddles both domains.
So here's the reframe, and it should change what you do tonight. Anatomy isn't a subject you master for eight isolated points. It is prerequisite knowledge the current plan threads into task and knowledge statements across sections carrying 84 scored items. That is not an 84-question anatomy claim. It is the reason median-cubital anatomy, injection sites and lead placement deserve more attention than an exhaustive list you cannot connect to a clinical task.
→ See the full domain weighting on the CCMA exam hub — all seven domains, item counts, and where the 84 Clinical items sit. It's the fastest way to see whether A&P deserves another hour of your time or none.
What does my score on this drill actually mean?
It describes how you did on these specific sampled questions and nothing more. It cannot be converted into an NHA scaled score, cannot tell you which eight A&P items you'll see, and cannot predict whether you'll pass. Use the statement-level results to pick what to review next.
Your result screen shows three things: a total for the session, separate results for 2A and 2B, and a line for each statement k35–k42. On the Full 24, each statement gets three questions, so we band them:
| Your result on one statement | What we call it | What to do |
|---|---|---|
| 0 or 1 of 3 | Review first | Relearn the concept, then come back for a fresh item |
| 2 of 3 | Partial recall | Review the specific distinction you missed, practice once more |
| 3 of 3 | Sampled strength | Keep it in light rotation — three questions isn't mastery |
Those are Castleport study-routing bands. They are not NHA score-report categories and they don't correspond to anything NHA publishes.
On Quick 8 you'll see "Correct in this sample" or "Missed in this sample" per statement. That's deliberate. You won't see Pass, Fail, Ready, or a predicted score anywhere on this page, because none of those would be true.
Why we won't give you a percentage-to-pass conversion. NHA scores the exam on a scaled score running from 200 to 500, with 390 as the passing standard. There's no public formula for turning raw questions correct into a scaled score. So "you need 70%" or "you got 82%, you're ready" is guesswork dressed as data. If you see a free domain quiz telling you 70% is passing, that's that site's own rule, not NHA's standard.
→ Got misses? Jump to the full question library — every question, answer and rationale is on this page in plain text, so you can turn your misses into tonight's study list without retaking anything.
I got "Below" on Anatomy and Physiology on my score report. Now what?
The official plan allocates eight scored items to A&P. The score report gives a diagnostic category, but NHA does not publish your raw A&P misses or the boundary between Above, Near and Below. Treat the rating as a signal to review, not as proof that anatomy is your biggest problem.
Three things worth knowing if this is you.
"Near" does not mean satisfactory performance in that content area. The handbook is explicit. Keep A&P in the review plan; do not read Near as a domain-level pass.
Don't drop what came back Above. The categories are ranges, not scores, and they can't be added together. Above doesn't mean finished.
The retake instruction has a wrinkle for this domain. NHA tells candidates to review the tasks associated with each content area rated Near or Below. Domain 2 has no task statements — it's eight knowledge statements and nothing else. So for A&P specifically, that instruction points at a list that doesn't exist. What you review instead is k35 through k42, and the fastest way to find out which of the eight is soft is to run the Full 24 above and read your statement lines.
And then, honestly: check whether A&P is even where your points went. Eight items is 5.3% of the scored exam. Clinical Patient Care is 84 items. A Below on A&P should not automatically consume more study time than a Near on Clinical. Read the category beside the blueprint weight. The hub has the full weighting and the current retake timeline.
How were these CCMA anatomy and physiology practice questions written?
We mapped the eight current Domain 2 knowledge statements from NHA's published test plan, wrote three original multiple-choice questions for each, then verified the medical fact behind every correct answer against a government or NIH-hosted clinical source. The test plan told us the scope. It did not tell us the answers.
That distinction is the core of how we work, so let's be concrete about it.
The test plan says k38 covers organ-system interactions and homeostasis. It doesn't say what happens to blood glucose after a meal. For that we went to the clinical literature. Every question on this page carries its own source link — CDC for stroke warning signs, epidemiology definitions and heart-disease risk factors; NIDDK for kidney function and type 1 diabetes; NHLBI for asthma; the National Cancer Institute for biopsy and chemotherapy; MedlinePlus for gas exchange and fractures; NCBI Bookshelf for cell structure, anatomy terms and thermoregulation. Click any of them.
What we actually verified
- Read the NHA CCMA Detailed Test Plan in full on August 11, 2026 — confirmed Domain 2 at 8 scored items, both subdomains, statements k35–k42, and zero task statements.
- Read the 2016 summary test plan, still live on NHA's site, and confirmed the older 12 items, 8%, and Microbiology as a third subdomain.
- Read NHA's 2016-to-2022 CCMA crosswalk and mapped old Microbiology statements to current k35 and k92–k94.
- Read the NHA Candidate Handbook, revision dated June 1, 2026, on scaled scoring, the 390 standard, performance categories, the five-or-fewer N/A rule, retake guidance, practice-test limits, pretest items and exam confidentiality.
- Classified the 25 explicit cross-domain task and knowledge statements in the map above under the counting rule we published.
- Rechecked the named free A&P quiz, Study.com weight table and Quizlet set on August 11, 2026.
- Checked the live Castleport 25-question diagnostic, 50-card flashcard page and CCMA Exam System launch page.
- Verified the clinical fact behind each of the 24 correct answers against the linked source.
What we did not do, and won't claim. We have no access to live exam items. We don't know NHA's undisclosed raw-to-scaled conversion. We don't know how the eight A&P items divide across k35–k42. We don't know whether the live 25-question Castleport diagnostic always contains a fixed number of A&P items. We're not predicting your result. And there's no clinical reviewer named on this page, because none has reviewed it.
Found a question or a source you think is wrong? Tell us and include the question ID. We'd rather fix it than defend it.
Are these real NHA CCMA exam questions?
No. Every question on this page is an original Castleport item written from the public test plan. None is copied, recalled, reconstructed or leaked from a live exam. The NHA Candidate Handbook requires candidates to agree not to reproduce, memorize, solicit, discuss or disclose exam questions.
"Mapped to the blueprint" means something specific here: the concept comes from a published statement, the question stem and all four options are ours, the clinical fact is independently sourced, and we make no claim about how NHA words its own items or how hard they are.
If a site offers you "actual CCMA questions," "recalled items," or a downloadable dump, think about what accepting it means. The candidate attestation prohibits that material. We won't link to those sources and we won't compete with them on that ground.
How our A&P drill compares to the free alternatives
Our drill isn't the biggest CCMA resource available. Among the free resources rechecked for this page on August 11, 2026, it is the only one in the comparison below built to all eight current A&P statements, with 2B included, no invented pass line, and a source on every answer.
Disclosure: Castleport Test Prep publishes the diagnostic, flashcards and drill rows below.
| Resource | What we verified | Current-blueprint signal | Result language |
|---|---|---|---|
| CCMA Practice Exam A&P quiz | 20 A&P questions; 15 listed topics | Listed topics map to 2A and do not name k39–k42 | Labels 70% as passing and prints PASS |
| Study.com CCMA practice page | Mixed CCMA practice page | Publishes the retired 10% / 8% / 54% / 5% / 13% / 5% / 5% weight pattern | General practice result |
| Quizlet "NHA CCMA: Anatomy & Physiology" set | Flashcard set | Description still says Microbiology and "12 questions" | No certification pass line in the description reviewed |
| Castleport all-domain diagnostic | 25 mixed-domain questions | Current plan; A&P is 1.3 expected items under proportional math, not a promised fixed mix | Domain breakdown; no pass prediction |
| Castleport CCMA flashcards | 50 cards across all seven domains; 3 A&P cards | Current plan; recall tool, not an A&P diagnosis | No pass line |
| This drill | 24 A&P questions | All 8 current statements; 12 questions in 2B | Study-routing bands only |
Where they beat us, plainly: Study.com and Quizlet give you more total material. If your goal is repetition volume, they'll give you more of it than this page will. Our 24 items are capped on purpose — we cover every statement three times and stop, because more volume is not a substitute for current-plan coverage.
These pages change. The comparison is a dated snapshot, not a permanent claim.
What should I do after this drill?
Pick one action based on your pattern. One weak statement means review that concept and retest it. Several weak 2A statements means rebuild structures and systems. Several weak 2B statements means study disease processes and epidemiology. A clean A&P result means A&P isn't your problem — go find out what is.
| Your result | Next step |
|---|---|
| One statement weak | Review that concept, then run a fresh Quick 8 |
| Several 2A misses | Rebuild cells, positions, systems and homeostasis — then Full 24 |
| Several 2B misses | Study disease signs and causes, diagnostics, incidence and risk, epidemics |
| You know definitions but miss scenarios | Repeat the Full 24 after reviewing the rationales |
| Basic recall is the problem | Use the 50 free CCMA flashcards |
| A&P looks solid, rest of exam unknown | Take the free CCMA diagnostic and find your weakest top-level domain |
| Test date is inside two weeks | Weight your hours by official item counts. Clinical is 84 items; A&P is 8 |
| Retaking after a Below on A&P | Full 24, read your statement lines, then check the retake timeline on the hub |
We're also building a full CCMA Exam System — a structured study guide covering all seven domains and an original question bank with full rationales. It isn't finished and isn't for sale, so there's nothing to buy here today. If you want to know when it's live, there's a launch list. That's a notification signup, not a checkout.
All 24 questions, answers and sources
Everything the drill contains, in plain text, so you can study it without retaking anything. The interactive version above adds feedback on whichever option you pick.
2A — Body Structures and Organ Systems
k35 · Cell structure
1. A cell's demand for ATP rises during active transport. Which organelle is most directly responsible for generating most of the cell's ATP?
A. Lysosome · B. Ribosome · C. Mitochondrion · D. Nucleus
Answer: Mitochondrion. Mitochondria generate most of the usable energy from nutrients and convert it to ATP through oxidative phosphorylation. Lysosomes break down cellular material; ribosomes build proteins; the nucleus stores genetic information.
Source: NCBI Bookshelf — Mitochondria
2. Which cell structure acts as a selective barrier between the cell's internal contents and the external environment?
A. Plasma membrane · B. Cytoplasm · C. Nucleolus · D. Lysosome
Answer: Plasma membrane. The plasma membrane encloses the cell and works as a selective barrier that maintains cellular integrity.
Source: NCBI Bookshelf — Histology, Cell
3. A cell is assembling a new protein from amino acids. Which structure performs the protein-synthesis step?
A. Mitochondrion · B. Lysosome · C. Plasma membrane · D. Ribosome
Answer: Ribosome. Ribosomes are the cellular structures that carry out protein synthesis.
Source: NCBI Bookshelf — From RNA to Protein
k36 · Anatomical structures, locations and positions
4. A patient is lying flat on the back with the face upward. Which position should the medical assistant document?
A. Prone · B. Supine · C. Lateral · D. Fowler's
Answer: Supine. Supine is lying on the back. Prone is lying on the abdomen; lateral is side-lying.
Source: NCBI Bookshelf — Medical Language Related to the Whole Body
5. Relative to the elbow, the wrist is in which anatomical direction?
A. Proximal · B. Superior · C. Medial · D. Distal
Answer: Distal. Distal means farther from the point of attachment along a limb. The wrist is farther from the trunk than the elbow is.
6. Which structure separates the thoracic cavity from the abdominopelvic cavity?
A. Sternum · B. Diaphragm · C. Peritoneum · D. Mediastinum
Answer: Diaphragm. The diaphragm forms the floor of the thoracic cavity and separates it from the abdominopelvic cavity.
Source: NCBI Bookshelf — Body Cavities
k37 · Major body systems, organs, structure and function
7. At which respiratory structure does oxygen move into the bloodstream while carbon dioxide moves from the blood into the lungs?
A. Alveoli · B. Trachea · C. Epiglottis · D. Pleura
Answer: Alveoli. Gas exchange happens across the closely associated walls of the alveoli and pulmonary capillaries.
Source: MedlinePlus — Gas Exchange
8. Which organ pair filters blood, removes wastes and extra water, and forms urine?
A. Adrenal glands · B. Ureters · C. Kidneys · D. Lymph nodes
Answer: Kidneys. The kidneys filter blood and remove wastes and extra water to make urine. The ureters transport it.
9. Which organ releases insulin after blood glucose rises following a meal?
A. Thyroid gland · B. Pancreas · C. Spleen · D. Gallbladder
Answer: Pancreas. Islet cells in the pancreas release insulin when blood glucose rises, helping glucose move from the blood into cells.
Source: NCBI Bookshelf — How the Pancreas Works
k38 · Organ-system interactions and homeostasis
10. Blood glucose rises after a meal. Which response helps return it toward its usual range?
A. Glucagon release causes the liver to release more glucose · B. Sweat glands increase evaporative cooling · C. The kidneys stop filtering blood · D. Insulin release increases glucose uptake by body cells
Answer: Insulin release increases glucose uptake by body cells. Insulin release that increases glucose uptake is a negative-feedback response. Glucagon does the opposite job, raising glucose when it falls too low.
11. Which event best demonstrates the respiratory and cardiovascular systems working together?
A. Bile is stored in the gallbladder until digestion · B. A ribosome assembles a protein in the cytoplasm · C. Oxygen diffuses from alveoli into capillary blood while carbon dioxide moves into the alveoli · D. The bladder stores urine before elimination
Answer: Oxygen diffuses from alveoli into capillary blood while carbon dioxide moves into the alveoli. Gas exchange at the alveoli and capillaries is the interface where the respiratory system meets the cardiovascular system.
Source: MedlinePlus — Gas Exchange
12. A healthy person becomes overheated during exercise. Which paired response most directly increases heat loss?
A. Cutaneous vasodilation and sweating · B. Cutaneous vasoconstriction and shivering · C. Insulin release and glycogen formation · D. Pupil constriction and salivation
Answer: Cutaneous vasodilation and sweating. Skin vessels dilate and sweat evaporates, dissipating heat. Vasoconstriction and shivering are cold responses.
Source: NCBI Bookshelf — Physiology, Integument
2B — Pathophysiology and Disease Processes
k39 · Signs, symptoms and causes of common diseases and injuries
13. A patient suddenly develops one-sided facial weakness and trouble speaking. Which condition should be suspected as an emergency?
A. Seasonal allergic rhinitis · B. Osteoarthritis · C. Gastroesophageal reflux · D. Stroke
Answer: Stroke. Sudden one-sided weakness and sudden trouble speaking are stroke warning signs. Activate emergency services immediately.
14. Which mechanism is most closely associated with type 1 diabetes?
A. The gallbladder stops storing bile · B. The immune system mistakenly attacks insulin-producing pancreatic cells · C. The thyroid produces too much calcitonin · D. The kidneys produce too much urine because of a blocked ureter
Answer: The immune system mistakenly attacks insulin-producing pancreatic cells. Type 1 diabetes develops when an autoimmune process damages insulin-producing pancreatic cells.
Source: NIDDK — Type 1 Diabetes
15. Which pathophysiologic change best explains wheezing and shortness of breath during an asthma flare?
A. The airways become inflamed and narrowed · B. The alveoli permanently fill with bone tissue · C. The kidneys stop producing erythropoietin · D. The stomach stops producing acid
Answer: The airways become inflamed and narrowed. Asthma affects the airways. During a flare, inflammation and narrowing make airflow harder and can cause wheezing.
Source: NHLBI — What Is Asthma?
k40 · Diagnostic measures and treatment modalities
16. A patient has focal bone pain and deformity after a fall. Which imaging study is commonly used first to check for a fracture?
A. Electrocardiogram · B. Spirometry · C. Plain X-ray · D. Audiometry
Answer: Plain X-ray. A skeletal X-ray is commonly used first to evaluate a suspected fracture after injury.
Source: MedlinePlus — Fractures
17. A provider needs a sample of an abnormal skin lesion examined under a microscope. Which procedure should the medical assistant expect?
A. Spirometry · B. Biopsy · C. Electrocardiography · D. Urinalysis
Answer: Biopsy. A biopsy removes cells or tissue so a pathologist can examine the sample under a microscope.
18. An oncology patient receives drugs intended to kill cancer cells or stop them from growing and dividing. Which treatment modality is this?
A. Biopsy · B. Radiography · C. Spirometry · D. Chemotherapy
Answer: Chemotherapy. Chemotherapy uses drugs to kill cancer cells or stop them from growing. Biopsy and radiography are diagnostic procedures, not this drug treatment.
Source: National Cancer Institute — Chemotherapy
k41 · Incidence, prevalence, risk factors and comorbidities
19. A county health department counts only the people newly diagnosed with measles during June. Which measure is it calculating?
A. Prevalence · B. Comorbidity · C. Incidence · D. Mortality proportion
Answer: Incidence. Incidence counts new cases beginning in a specified period. Prevalence also includes people who already had the condition.
20. A patient is being treated for both hypertension and type 2 diabetes at the same time. Which term best describes this?
A. Comorbidity · B. Incidence · C. Epidemic · D. Remission
Answer: Comorbidity. Comorbidity means two or more diseases or conditions are present at the same time.
21. Which option is a modifiable risk factor for heart disease?
A. Age · B. Family history · C. Cigarette smoking · D. Sex
Answer: Cigarette smoking. Cigarette smoking is a behavior that can be changed. Age, family history, and sex are not modifiable risk factors.
Source: CDC — Heart Disease Risk Factors
k42 · Epidemics and pandemics
22. A nursing home reports substantially more cases of the same respiratory illness than normally expected over two weeks. Which term best fits?
A. Outbreak · B. Comorbidity · C. Remission · D. Endocrine feedback
Answer: Outbreak. An outbreak is an increase in cases above what is normally expected in a defined time, place, or population; the term is often used for a limited geographic area.
23. A state usually records 10 cases of a disease each month but records 85 this month across several counties. Which term best fits the increase?
A. Pandemic · B. Epidemic · C. Comorbidity · D. Remission
Answer: Epidemic. An epidemic is an increase in cases above what is normally expected in a population and area. The scenario does not establish spread across several countries or continents.
24. Disease transmission has expanded across several countries on multiple continents and is affecting large numbers of people. Which classification best fits?
A. Localized outbreak · B. Comorbidity · C. Endemic disease in one area · D. Pandemic
Answer: Pandemic. A pandemic is an epidemic that has spread across several countries or continents, usually affecting many people.
Source: CDC — Principles of Epidemiology, Section 11
Frequently asked questions
Is CCMA anatomy and physiology 8 questions or 12? Eight under the current plan. Twelve came from the plan based on NHA's 2016 job analysis, which also listed Microbiology as an A&P subdomain. The current plan is based on the 2022 job analysis, and NHA made the current CCMA 3.0 exam available January 10, 2024. Both PDFs remain online, which is why the old number persists.
Are the 30 pretest questions identified during the exam? No. The Candidate Handbook says candidates are not aware which questions are scored and which are pretest. The pretest questions do not affect the official score.
What score do I need to pass the CCMA exam? NHA reports a scaled score from 200 to 500 with 390 as the passing standard. Don't divide 390 by 500, and don't convert a practice percentage into a predicted scaled score — no public raw-to-scaled conversion exists.
Is 70% on an A&P practice quiz a passing score? No NHA pass line applies to a third-party domain quiz. A 70% label is that publisher's own rule, not NHA's certification standard. Use your statement-level results to direct study instead.
Does my CCMA score report show Anatomy and Physiology separately? NHA says the detailed report shows diagnostic performance across major content areas that line up with the test plan. Under the current plan, A&P is an 8-item domain and clears the handbook's five-or-fewer N/A threshold. The public handbook does not say an official item count is printed next to the row.
Are these official NHA questions? No. They're original Castleport questions written to the public test plan. We're an independent publisher and we don't possess, solicit or publish live, recalled or leaked NHA items.
Does the real exam group all the A&P questions together? We don't know, and we're not going to guess. The test plan lists domains in order, but nothing in the current public plan or handbook establishes that candidates receive questions grouped by domain.
What body systems should I study for the CCMA? Statement k37 covers major body systems, organs, and their structure and function without publishing a required system-by-system list. Prioritize the systems the plan explicitly reuses elsewhere: cardiovascular for pulse and EKG, respiratory for respiration and spirometry, skin and vascular anatomy for injections and phlebotomy, and eye and ear anatomy for tests, medications and irrigation.
Are flashcards or practice questions better for CCMA A&P? Use flashcards when you cannot recall the term or function. Use practice questions when you know the words but miss the clinical distinction or scenario. Castleport's free CCMA flashcards handle recall; this drill handles sampled application.
Can I use this for the AAMA CMA exam? Not as a blueprint-matched set. The CMA is a different credential from a different organization with its own content outline. Start at CMA vs CCMA vs RMA.
How often should I retake Quick 8? After you've reviewed what you missed, not straight from memory. Quick 8 draws one of the three available questions for each statement, but one sampled item still cannot prove mastery.
Does a high score here mean I'll pass? No. NHA's handbook warns that a high practice-test score doesn't guarantee passing. Treat a strong result as one sample and keep the bigger domains in view — Clinical Patient Care alone is 84 of the 150 scored items.
Not sure where you stand across the whole exam? Take the free Castleport CCMA diagnostic — 25 questions, instant results by domain, no sign-up required. It won't resolve A&P on its own; that's what the drill at the top of this page is for. But it'll tell you which top-level domain to work on first.
This page is exam-preparation guidance. It is not medical, legal, employment or licensing advice. Medical assistant scope of practice varies by state — confirm what applies to you with your state's regulator.
Independence disclosure: Castleport Test Prep is an independent publisher of exam-preparation materials. We are not affiliated with, endorsed by, approved by, or connected to the National Healthcareer Association (NHA), any testing vendor, licensing board, or certification body. Exam and credential names are used descriptively for identification only. Castleport does not claim ownership of third-party names or marks.
Castleport Test Prep Editorial Team · Last verified August 11, 2026 · Question bank version 1.0